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HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2

Preeclampsia is a serious pregnancy disorder that lacks effective treatments other than delivery. Improper sensing of oxygen changes during placentation by prolyl hydroxylases (PHDs), specifically PHD2, causes placental hypoxia-inducible factor-1 (HIF1) buildup and abnormal downstream signaling in e...

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Principais autores: Julien Sallais, Chanho Park, Sruthi Alahari, Tyler Porter, Ruizhe Liu, Merve Kurt, Abby Farrell, Martin Post, Isabella Caniggia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical investigation 2022-12-01
coleção:JCI Insight
Assuntos:
Development
Reproductive biology
Acesso em linha:https://doi.org/10.1172/jci.insight.158908
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