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IL-1α, IL-1β, and IFN-γ mark β cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes

Cytokines such as IL-1α, IL-1β, and IFN-γ have long been implicated in the pathogenesis of autoimmune diabetes, but the mechanisms through which they promote diabetogenesis remain unclear. Here we show that CD4(+) T lymphocytes propagated from transgenic nonobese diabetic (NOD) mice expressing the h...

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Detalhes bibliográficos
Main Authors: Amrani, Abdelaziz, Verdaguer, Joan, Thiessen, Shari, Bou, Sonny, Santamaria, Pere
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC289158/
https://ncbi.nlm.nih.gov/pubmed/10683375
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