Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2

To investigate roles in intestinal inflammation for the 2 cyclooxygenase (COX) isoforms, we determined susceptibility to spontaneous and induced acute colitis in mice lacking either the COX-1 or COX-2 isoform. We treated wild-type, COX-1(–/–), COX-2(–/–), and heterozygous mice with dextran sodium su...

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Main Authors: Morteau, Olivier, Morham, Scott G., Sellon, Rance, Dieleman, Levinus A., Langenbach, Robert, Smithies, Oliver, Sartor, R. Balfour
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC289156/
https://ncbi.nlm.nih.gov/pubmed/10683376
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