Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2

To investigate roles in intestinal inflammation for the 2 cyclooxygenase (COX) isoforms, we determined susceptibility to spontaneous and induced acute colitis in mice lacking either the COX-1 or COX-2 isoform. We treated wild-type, COX-1(–/–), COX-2(–/–), and heterozygous mice with dextran sodium su...

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Publicado en:	J Clin Invest
Autores principales:	Morteau, Olivier, Morham, Scott G., Sellon, Rance, Dieleman, Levinus A., Langenbach, Robert, Smithies, Oliver, Sartor, R. Balfour
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 2000
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC289156/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10683376/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI6899
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