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Characterization of the acetylation of cyclooxygenase-isozymes and targeted lipidomics of eicosanoids in serum and colon cancer cells by the new aspirin formulation IP1867B versus aspirin in vitro

Background: Aspirin(acetylsalicylic acid, ASA) is recommended for the secondary prevention of atherothrombotic events and has shown anticancer effects. The current enteric-coated drug formulation may reduce aspirin bioavailability. Liquid formulations could improve aspirin pharmacokinetics and pharm...

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Principais autores: Ulrika Hofling, Stefania Tacconelli, Annalisa Contursi, Annalisa Bruno, Matteo Mucci, Patrizia Ballerini, Simon Cohen, Paola Patrignani
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-12-01
Serier:Frontiers in Pharmacology
Fag:
aspirin
IP1867B
platelet
serum
HCA7 cells
cyclooxygenases
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2022.1070277/full
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