Therapeutic targeting of the PDGF and TGF-β-signaling pathways in hepatic stellate cells by PTK787/ZK22258

Stimulation of hepatic stellate cells (HSCs) by platelet-derived growth factor (PDGF) and transforming growth factor-β1 (TGF-β1) is an essential pathway of proliferation and fibrogenesis, respectively, in liver fibrosis. We provide evidence that PTK787/ZK222584 (PTK/ZK), a potent tyrosine kinase inh...

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Hlavní autoři: Liu, Yuqing, Wen, Xiao Ming, Lui, Eric Lik Hang, Friedman, Scott L, Cui, Wei, Ho, Nancy Pei Shan, Li, Lei, Ye, Tao, Fan, Sheung Tat, Zhang, Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891536/
https://ncbi.nlm.nih.gov/pubmed/19668241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2009.77
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