PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling

Liver fibrosis due to hepatic stellate cell (HSC) activation represents a common response to chronic liver injury. PTK787/ZK222584 (PTK/ZK) is a pan-VEGFR tyrosine kinase inhibitor. The aim of this study was to examine the effect of PTK/ZK in liver fibrosis. In primary HSCs, PTK/ZK inhibited the exp...

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Detalhes bibliográficos
Main Authors: Liu, Yuqing, Lui, Eric Lik Hang, Friedman, Scott L, Li, Lei, Ye, Tao, Chen, Yongjun, Poon, Ronnie T, Wo, Jana, Kok, Tsz Wai, Fan, Sheung Tat
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888529/
https://ncbi.nlm.nih.gov/pubmed/19114984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2008.127
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