The pharmacological stressor yohimbine increases impulsivity through activation of CREB in the orbitofrontal cortex

BACKGROUND: Stress can increase impulsivity, and has a negative impact on psychiatric outcome. Norepinephrine is heavily implicated in the stress response, and the alpha-2 antagonist yohimbine is used clinically as a pharmacological stressor. Yohimbine induces mild anxiety and increases impulsivity...

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Detalhes bibliográficos
Main Authors: Sun, HaoSheng, Green, Tom A., Theobald, David E.H., Laali, Samuel, Shrikhande, Gayatri, Birnbaum, Shari, Kumar, Arvind, Chakravarty, Sumana, Graham, Danielle, Nestler, Eric J., Winstanley, Catharine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891518/
https://ncbi.nlm.nih.gov/pubmed/20163788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2009.11.030
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