Photoreceptor Degeneration, Azoospermia, Leukoencephalopathy, and Abnormal RPE Cell Function in Mice Expressing an Early Stop Mutation in CLCN2

PURPOSE. To determine the molecular basis and the pathologic consequences of a chemically induced mutation in a mouse model of photoreceptor degeneration, nmf240. METHODS. Mice from a G3 N-ethyl-N-nitrosourea mutagenesis program were screened by indirect ophthalmoscopy for abnormal fundi. A chromoso...

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Detalhes bibliográficos
Main Authors: Edwards, Malia M., de Evsikova, Caralina Marín, Collin, Gayle B., Gifford, Elaine, Wu, Jiang, Hicks, Wanda L., Whiting, Carrie, Varvel, Nicholas H., Maphis, Nicole, Lamb, Bruce T., Naggert, Jürgen K., Nishina, Patsy M., Peachey, Neal S.
Formato: Artigo
Idioma:Inglês
Publicado em: Association for Research in Vision and Ophthalmology, Inc. 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891478/
https://ncbi.nlm.nih.gov/pubmed/20071672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-4887
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