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Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2

Cyclooxygenase-1 and -2 are rate-limiting enzymes in the formation of a wide array of bioactive lipid mediators collectively known as prostanoids (prostaglandins, prostacyclins, thromboxanes). Evidence from clinical trials shows that selective inhibition of the second isoenzyme (cyclooxygenase-2, or...

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Detalhes bibliográficos
Main Authors: Papanicolaou, Kyriakos N., Streicher, John M., Ishikawa, Tomo-o, Herschman, Harvey, Wang, Yibin, Walsh, Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891277/
https://ncbi.nlm.nih.gov/pubmed/20399788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.04.002
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