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Activation of lecithin:cholesterol acyltransferase by HDL ApoA-I central helices

Lecithin:cholesterol acyltransferase (LCAT) is an enzyme that first hydrolyzes the sn-2 position of phospholipids, preferentially a diacylphosphocholine, and then transfers the fatty acid to cholesterol to yield a cholesteryl ester. HDL ApoA-I is the principal catalytic activator for LCAT. Activity...

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Bibliographic Details
Main Authors: Sorci-Thomas, Mary G, Bhat, Shaila, Thomas, Michael J
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891274/
https://ncbi.nlm.nih.gov/pubmed/20582235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/17584299.4.1.113
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