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Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells

Thioredoxin reductase (TrxR) is a selenocysteine-containing flavoprotein that catalyzes the NADPH-dependent reduction of oxidized thioredoxin and plays a key role in regulating cellular redox homeostasis. In the present studies we examined the effects of 2-chloroethyl ethyl sulfide (CEES), a model s...

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Hlavní autoři: Jan, Yi-Hua, Heck, Diane E., Gray, Joshua P., Zheng, Haiyan, Casillas, Robert P., Laskin, Debra L., Laskin, Jeffrey D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891120/
https://ncbi.nlm.nih.gov/pubmed/20345183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx100040k
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