Mutant presenilin-1 deregulated peripheral immunity exacerbates Alzheimer-like pathology

Mutations in the presenilin-1 (PS1) gene are independent causes of familial Alzheimer's disease (AD). AD patients have dysregulated immunity, and PS1 mutant mice exhibit abnormal systemic immune responses. To test whether immune function abnormality caused by a mutant human PS1 gene (mhPS1) cou...

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Detalhes bibliográficos
Main Authors: Zhu, Yuyan, Obregon, Demian, Hou, Huayan, Giunta, Brian, Ehrhart, Jared, Fernandez, Frank, Mori, Takashi, Nikolic, William, Zhao, Yangbing, Morgan, Dave, Town, Terrence, Tan, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891003/
https://ncbi.nlm.nih.gov/pubmed/19900216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00962.x
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