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NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes

The phagosomal lumen in macrophages is the site of numerous interacting chemistries that mediate microbial killing, macromolecular degradation, and antigen processing. Using a non-hypothesis-based screen to explore the interconnectivity of phagosomal functions, we found that NADPH oxidase (NOX2) neg...

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Detalhes bibliográficos
Main Authors: Rybicka, Joanna M., Balce, Dale R., Khan, Morgan F., Krohn, Regina M., Yates, Robin M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890838/
https://ncbi.nlm.nih.gov/pubmed/20498052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914867107
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