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NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes

The phagosomal lumen in macrophages is the site of numerous interacting chemistries that mediate microbial killing, macromolecular degradation, and antigen processing. Using a non-hypothesis-based screen to explore the interconnectivity of phagosomal functions, we found that NADPH oxidase (NOX2) neg...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rybicka, Joanna M., Balce, Dale R., Khan, Morgan F., Krohn, Regina M., Yates, Robin M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890838/
https://ncbi.nlm.nih.gov/pubmed/20498052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914867107
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