Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma

Previous studies have shown that Th2 cytokine genes on mouse chromosome 11 are coordinately regulated by the Th2 locus control region (LCR). To examine the in vivo function of Th2 LCR, we generated CD4-specific Th2 LCR-deficient (cLCR KO) mice using Cre-LoxP recombination. The number of CD4 T cells...

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Detalhes bibliográficos
Main Authors: Koh, Byung Hee, Hwang, Soo Seok, Kim, Joo Young, Lee, Wonyong, Kang, Min-Jong, Lee, Chun Geun, Park, Jung-Won, Flavell, Richard A., Lee, Gap Ryol
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890814/
https://ncbi.nlm.nih.gov/pubmed/20483988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005383107
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