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The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
High-affinity, high-selectivity protein-protein interactions that are critical for cell survival present an evolutionary paradox: How does selectivity evolve when acquired mutations risk a lethal loss of high-affinity binding? A detailed understanding of selectivity in such complexes requires struct...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890441/ https://ncbi.nlm.nih.gov/pubmed/20479265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910756107 |
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