The Oral Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Increases Circulating Endothelial Progenitor Cells in Patients With Type 2 Diabetes: Possible role of stromal-derived factor-1α

OBJECTIVE: Vasculoprotective endothelial progenitor cells (EPCs) are regulated by stromal-derived factor-1α (SDF-1α) and are reduced in type 2 diabetes. Because SDF-1α is a substrate of dipeptidyl-peptidase-4 (DPP-4), we investigated whether the DPP-4 inhibitor sitagliptin modulates EPC levels in ty...

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Detalhes bibliográficos
Main Authors: Fadini, Gian Paolo, Boscaro, Elisa, Albiero, Mattia, Menegazzo, Lisa, Frison, Vera, de Kreutzenberg, Saula, Agostini, Carlo, Tiengo, Antonio, Avogaro, Angelo
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890368/
https://ncbi.nlm.nih.gov/pubmed/20357375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/dc10-0187
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