Combination of Myostatin Pathway Interference and Dystrophin Rescue Enhances Tetanic and Specific Force in Dystrophic mdx Mice

Duchenne muscular dystrophy is characterized by muscular atrophy, fibrosis, and fat accumulation. Several groups have demonstrated that in the mdx mouse, the exon-skipping strategy can restore a quasi-dystrophin in almost 100% of the muscle fibers. On the other hand, inhibition of the myostatin path...

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Bibliographische Detailangaben
Hauptverfasser: Dumonceaux, Julie, Marie, Solenne, Beley, Cyriaque, Trollet, Capucine, Vignaud, Alban, Ferry, Arnaud, Butler-Browne, Gillian, Garcia, Luis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890116/
https://ncbi.nlm.nih.gov/pubmed/20104211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.322
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