Combination of Myostatin Pathway Interference and Dystrophin Rescue Enhances Tetanic and Specific Force in Dystrophic mdx Mice

Duchenne muscular dystrophy is characterized by muscular atrophy, fibrosis, and fat accumulation. Several groups have demonstrated that in the mdx mouse, the exon-skipping strategy can restore a quasi-dystrophin in almost 100% of the muscle fibers. On the other hand, inhibition of the myostatin path...

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Detalhes bibliográficos
Main Authors: Dumonceaux, Julie, Marie, Solenne, Beley, Cyriaque, Trollet, Capucine, Vignaud, Alban, Ferry, Arnaud, Butler-Browne, Gillian, Garcia, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890116/
https://ncbi.nlm.nih.gov/pubmed/20104211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.322
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