Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle

BACKGROUND: The greater susceptibility to contraction-induced skeletal muscle injury (fragility) is an important dystrophic feature and tool for testing preclinic dystrophin-based therapies for Duchenne muscular dystrophy. However, how these therapies reduce the muscle fragility is not clear. METHOD...

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Detalhes bibliográficos
Publicado no:Skelet Muscle
Main Authors: Roy, Pauline, Rau, Fredérique, Ochala, Julien, Messéant, Julien, Fraysse, Bodvael, Lainé, Jeanne, Agbulut, Onnik, Butler-Browne, Gillian, Furling, Denis, Ferry, Arnaud
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4952281/
https://ncbi.nlm.nih.gov/pubmed/27441081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-016-0096-4
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