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Differential Requirement of CD27 Costimulatory Signaling for Naïve Versus Alloantigen-Primed Effector/Memory CD8(+) T Cells
CD8(+) memory T cells endanger allograft survival by causing acute and chronic rejection and prevent tolerance induction. We explored the role of CD27:CD70 T-cell costimulatory pathway in alloreactive CD8(+)/CD4(+) T-cell activation. CD27-deficient (CD27(−/−)) and wild-type (WT) B6 mice rejected BAL...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889922/ https://ncbi.nlm.nih.gov/pubmed/20353477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2010.03089.x |
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