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Robust and Generic RNA Modeling Using Inferred Constraints: A Structure for the Hepatitis C Virus IRES Pseudoknot Domain
RNA function is dependent on its structure, yet three-dimensional folds for most biologically important RNAs are unknown. We develop a generic discrete molecular dynamics (DMD)-based modeling system that uses long-range constraints inferred from diverse biochemical or bioinformatic analyses to creat...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889920/ https://ncbi.nlm.nih.gov/pubmed/20545364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100142y |
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