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Structure modeling of RNA using sparse NMR constraints

RNAs fold into distinct molecular conformations that are often essential for their functions. Accurate structure modeling of complex RNA motifs, including ubiquitous non-canonical base pairs and pseudoknots, remains a challenge. Here, we present an NMR-guided all-atom discrete molecular dynamics (DM...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Williams, Benfeard, Zhao, Bo, Tandon, Arpit, Ding, Feng, Weeks, Kevin M., Zhang, Qi, Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728392/
https://ncbi.nlm.nih.gov/pubmed/29165648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1058
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