In vivo Regulation of the Allergic Response by the Interleukin 4 Receptor Alpha Chain Immunoreceptor Tyrosine-based Inhibitory Motif

BACKGROUND: Signaling by IL-4 and IL-13 via the IL-4 receptor alpha chain (IL-4Rα) plays a critical role in the pathology of allergic diseases. The IL-4Rα is endowed with an immunoreceptor tyrosine-based inhibitory motif (ITIM), centered on tyrosine 709 (Y709) in the cytoplasmic domain, that binds a...

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Autori principali: Tachdjian, Raffi, Khatib, Shadi Al, Schwinglshackl, Andreas, Kim, Hong Sook, Chen, Andrew, Blasioli, Julie, Mathias, Clinton, Kim, Hye-Young, Umetsu, Dale T., Oettgen, Hans C., Chatila, Talal A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889905/
https://ncbi.nlm.nih.gov/pubmed/20392476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2010.01.054
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