The Transcription Factor Rfx3 Regulates β-Cell Differentiation, Function, and Glucokinase Expression

OBJECTIVE: Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marked reduction in insulin-producing β-cells. The objective of this work was to unravel the cellular and molecular mechanisms underlying this deficiency. RESEARCH DESIGN AND METHODS: Immunofluorescence st...

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Main Authors: Ait-Lounis, Aouatef, Bonal, Claire, Seguín-Estévez, Queralt, Schmid, Christoph D., Bucher, Philipp, Herrera, Pedro L., Durand, Bénédicte, Meda, Paolo, Reith, Walter
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2010
Teme:
Islet Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889767/
https://ncbi.nlm.nih.gov/pubmed/20413507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0986
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