Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes

OBJECTIVE: Depletion of body fat stores during uncontrolled, insulin-deficient diabetes (uDM) results in markedly reduced plasma leptin levels. This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and neuroendocrine derangements indu...

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Autori principali: German, Jonathan P., Wisse, Brent E., Thaler, Joshua P., Oh-I, Shinsuke, Sarruf, David A., Ogimoto, Kayoko, Kaiyala, Karl J., Fischer, Jonathan D., Matsen, Miles E., Taborsky, Gerald J., Schwartz, Michael W., Morton, Gregory J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2010
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889761/
https://ncbi.nlm.nih.gov/pubmed/20424233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1918
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