Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes

OBJECTIVE: Depletion of body fat stores during uncontrolled, insulin-deficient diabetes (uDM) results in markedly reduced plasma leptin levels. This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and neuroendocrine derangements indu...

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Main Authors: German, Jonathan P., Wisse, Brent E., Thaler, Joshua P., Oh-I, Shinsuke, Sarruf, David A., Ogimoto, Kayoko, Kaiyala, Karl J., Fischer, Jonathan D., Matsen, Miles E., Taborsky, Gerald J., Schwartz, Michael W., Morton, Gregory J.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2010
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889761/
https://ncbi.nlm.nih.gov/pubmed/20424233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1918
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