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Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain

Viral gene transfer or transgenic animals are commonly used technologies to alter gene expression in the adult brain, although these approaches lack spatial specificity and are time consuming. We delivered plasmid DNA locally into the brain of adult C57BL/6 mice in vivo by voltage- and current-contr...

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Autores principales: Vry, Jochen De, Martínez-Martínez, Pilar, Losen, Mario, Bode, Gerard H, Temel, Yasin, Steckler, Thomas, Steinbusch, Harry WM, Baets, Marc De, Prickaerts, Jos
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889750/
https://ncbi.nlm.nih.gov/pubmed/20389292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.62
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