Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.

To analyze the signaling pathways utilized in malignant transformation by pp60v-src, we have isolated and characterized src mutants which possess normal levels of protein tyrosine kinase activity but which cause only a partially transformed phenotype. Our hypothesis is that such mutants are partiall...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Wages, D S, Keefer, J, Rall, T B, Weber, M J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288973/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1312609/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.4.1866-1874.1992
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