Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

Using a high-throughput chemical screen, we identified two small molecules that enhance the survival of human embryonic stem cells (hESCs). By characterizing their mechanisms of action, we discovered an essential role of E-cadherin signaling for ESC survival. Specifically, we showed that the primary...

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Bibliographic Details
Main Authors: Xu, Yue, Zhu, Xiuwen, Hahm, Heung Sik, Wei, Wanguo, Hao, Ergeng, Hayek, Alberto, Ding, Sheng
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889586/
https://ncbi.nlm.nih.gov/pubmed/20406903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002024107
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