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Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules
Using a high-throughput chemical screen, we identified two small molecules that enhance the survival of human embryonic stem cells (hESCs). By characterizing their mechanisms of action, we discovered an essential role of E-cadherin signaling for ESC survival. Specifically, we showed that the primary...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889586/ https://ncbi.nlm.nih.gov/pubmed/20406903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002024107 |
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