The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

Loss of Hippo signaling in Drosophila leads to tissue overgrowth as a result of increased cell proliferation and decreased cell death. YAP (a homolog of Drosophila Yorkie and target of the Hippo pathway) was recently implicated in control of organ size, epithelial tissue development, and tumorigenes...

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Bibliografiske detaljer
Main Authors: Lee, Kwang-Pyo, Lee, Joo-Hyeon, Kim, Tae-Shin, Kim, Tack-Hoon, Park, Hee-Dong, Byun, Jin-Seok, Kim, Min-Chul, Jeong, Won-Il, Calvisi, Diego F., Kim, Jin-Man, Lim, Dae-Sik
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889558/
https://ncbi.nlm.nih.gov/pubmed/20404163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912203107
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