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An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability

The Arp2/3 complex polymerizes new actin filaments from the sides of existing filaments, forming Y-branched networks that are critical for actin-mediated force generation. Binding of the Arp2/3 complex to the sides of actin filaments is therefore central to its actin-nucleating and branching activit...

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Autors principals: Goley, Erin D., Rammohan, Aravind, Znameroski, Elizabeth A., Firat-Karalar, Elif Nur, Sept, David, Welch, Matthew D.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889539/
https://ncbi.nlm.nih.gov/pubmed/20404198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911668107
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