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Functionally important conformations of the Met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuations
Conformational changes in enzymes are well recognized to play an important role in the organization of the reactive groups for efficient catalysis. This study reveals atomic and energetic details of the conformational change process that precedes the catalytic reaction of the enzyme dihydrofolate re...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889193/ https://ncbi.nlm.nih.gov/pubmed/19323547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9000135 |
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