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Conformational change of the methionine 20 loop of Escherichia coli dihydrofolate reductase modulates pK(a) of the bound dihydrofolate
We evaluate the pK(a) of dihydrofolate (H(2)F) at the N(5) position in three ternary complexes with Escherichia coli dihydrofolate reductase (ecDHFR), namely ecDHFR(NADP(+):H(2)F) in the closed form (1), and the Michaelis complexes ecDHFR(NADPH:H(2)F) in the closed (2) and occluded (3) forms, by per...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206655/ https://ncbi.nlm.nih.gov/pubmed/17473015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062724307 |
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