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Branched Intermediate Formation Stimulates Peptide Bond Cleavage in Protein Splicing

Protein splicing is a posttranslational modification in which an intein domain excises itself out of a host protein. Here, we investigate how the steps in the splicing process are coordinated so as to maximize the production of the final splice products and minimize the generation of undesired cleav...

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Detalhes bibliográficos
Main Authors: Frutos, Silvia, Goger, Michael, Giovani, Baldissera, Cowburn, David, Muir, Tom W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889191/
https://ncbi.nlm.nih.gov/pubmed/20495572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.371
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