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Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase.

Repeated passages of vaccinia virus in increasing concentrations of hydroxyurea followed by plaque purification resulted in the isolation of variants capable of growth in 5 mM hydroxyurea, a drug concentration which inhibited the reproduction of wild-type vaccinia virus 1,000-fold. Analyses of viral...

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Bibliographic Details
Main Authors: Slabaugh, M B, Mathews, C K
Format: Artigo
Language:Inglês
Published: 1986
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC288919/
https://ncbi.nlm.nih.gov/pubmed/3534300
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