Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase.
Repeated passages of vaccinia virus in increasing concentrations of hydroxyurea followed by plaque purification resulted in the isolation of variants capable of growth in 5 mM hydroxyurea, a drug concentration which inhibited the reproduction of wild-type vaccinia virus 1,000-fold. Analyses of viral...
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| Udgivet i: | J Virol |
|---|---|
| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1986
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288919/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3534300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.60.2.506-514.1986 |
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