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A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice
The nonobese diabetic (NOD) mouse strain has a genetic deficiency in natural killer (NK) cells. This defect underlies this strain's utility in several experimental settings; in particular, it promotes engraftment of human tissue in NOD hosts during the generation of “humanized” mouse models. We...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889097/ https://ncbi.nlm.nih.gov/pubmed/20439722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004492107 |
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