Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction

Mutations in mitochondrial oxidative phosphorylation complex I are associated with multiple pathologies, and complex I has been proposed as a crucial regulator of animal longevity. In yeast, the single-subunit NADH dehydrogenase Ndi1 serves as a non-proton-translocating alternative enzyme that repla...

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Detalhes bibliográficos
Main Authors: Sanz, Alberto, Soikkeli, Mikko, Portero-Otín, Manuel, Wilson, Angela, Kemppainen, Esko, McIlroy, George, Ellilä, Simo, Kemppainen, Kia K., Tuomela, Tea, Lakanmaa, Matti, Kiviranta, Essi, Stefanatos, Rhoda, Dufour, Eric, Hutz, Bettina, Naudí, Alba, Jové, Mariona, Zeb, Akbar, Vartiainen, Suvi, Matsuno-Yagi, Akemi, Yagi, Takao, Rustin, Pierre, Pamplona, Reinald, Jacobs, Howard T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889079/
https://ncbi.nlm.nih.gov/pubmed/20435911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911539107
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