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Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

The lipid kinase PIK3C3 (also called Vps34) regulates both the endosomal and autophagic pathways. However, the effect of inactivating PIK3C3 on neuronal endosomal versus autophagic processes in vivo has not been studied. We generated mice in which Pik3c3 was conditionally deleted in differentiated s...

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Main Authors: Zhou, Xiang, Wang, Liangli, Hasegawa, Hiroshi, Amin, Priyanka, Han, Bao-Xia, Kaneko, Shinjiro, He, Youwen, Wang, Fan
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2010
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889054/
https://ncbi.nlm.nih.gov/pubmed/20439739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914725107
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