Fractalkine and CX(3)CR1 regulate hippocampal neurogenesis in adult and aged rats

Microglia have neuroprotective capacities, yet chronic activation can promote neurotoxic inflammation. Neuronal fractalkine (FKN), acting on CX(3)CR1, has been shown to suppress excessive microglia activation. We found that disruption in FKN/ CX(3)CR1 signaling in young adult rodents decreased survi...

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Autori principali: Bachstetter, Adam D., Morganti, Josh M., Jernberg, Jennifer, Schlunk, Andrea, Mitchell, Staten H., Brewster, Kaelin W., Hudson, Charles E., Cole, Michael J, Harrison, Jeffrey K., Bickford, Paula C., Gemma, Carmelina
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889032/
https://ncbi.nlm.nih.gov/pubmed/20018408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2009.11.022
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