Fractalkine and CX(3)CR1 regulate hippocampal neurogenesis in adult and aged rats

Microglia have neuroprotective capacities, yet chronic activation can promote neurotoxic inflammation. Neuronal fractalkine (FKN), acting on CX(3)CR1, has been shown to suppress excessive microglia activation. We found that disruption in FKN/ CX(3)CR1 signaling in young adult rodents decreased survi...

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書誌詳細
主要な著者: Bachstetter, Adam D., Morganti, Josh M., Jernberg, Jennifer, Schlunk, Andrea, Mitchell, Staten H., Brewster, Kaelin W., Hudson, Charles E., Cole, Michael J, Harrison, Jeffrey K., Bickford, Paula C., Gemma, Carmelina
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889032/
https://ncbi.nlm.nih.gov/pubmed/20018408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2009.11.022
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