Fractalkine and CX(3)CR1 regulate hippocampal neurogenesis in adult and aged rats

Microglia have neuroprotective capacities, yet chronic activation can promote neurotoxic inflammation. Neuronal fractalkine (FKN), acting on CX(3)CR1, has been shown to suppress excessive microglia activation. We found that disruption in FKN/ CX(3)CR1 signaling in young adult rodents decreased survi...

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Detalhes bibliográficos
Main Authors: Bachstetter, Adam D., Morganti, Josh M., Jernberg, Jennifer, Schlunk, Andrea, Mitchell, Staten H., Brewster, Kaelin W., Hudson, Charles E., Cole, Michael J, Harrison, Jeffrey K., Bickford, Paula C., Gemma, Carmelina
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889032/
https://ncbi.nlm.nih.gov/pubmed/20018408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2009.11.022
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