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Antitumor Agents 268. Design, Synthesis, and Mechanistic Studies of New 9-Substituted Phenanthrene-based Tylophorine Analogs as Potent Cytotoxic Agents
Nineteen new phenanthrene-based tylophorine analogs with various functional groups on the piperidine moiety were designed, synthesized and evaluated for in vitro anticancer activity against four human tumor cell lines. Analogs 15 and 21 showed approximately two-fold enhanced inhibitory activity as c...
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主要な著者: | , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2009
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2888945/ https://ncbi.nlm.nih.gov/pubmed/19645447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9009263 |
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