Antitumor Agents 268. Design, Synthesis, and Mechanistic Studies of New 9-Substituted Phenanthrene-based Tylophorine Analogs as Potent Cytotoxic Agents

Nineteen new phenanthrene-based tylophorine analogs with various functional groups on the piperidine moiety were designed, synthesized and evaluated for in vitro anticancer activity against four human tumor cell lines. Analogs 15 and 21 showed approximately two-fold enhanced inhibitory activity as c...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Yang, Xiaoming, Shi, Qian, Liu, Yi-Nan, Zhao, Guiyu, Bastow, Kenneth F., Lin, Jau-Chen, Yang, Shuenn-Chen, Yang, Pan-Chyr, Lee, Kuo-Hsiung
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888945/
https://ncbi.nlm.nih.gov/pubmed/19645447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9009263
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