OSU-03012 enhances Ad.mda-7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins

The present studies focused on determining whether the autophagy-inducing drug OSU-03012 (AR-12) could enhance the toxicity of recombinant adenoviral delivery of melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) in glioblastoma multiforme (GBM) cells. The toxicity of a recombin...

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Main Authors: Hamed, Hossein A., Yacoub, Adly, Park, Margaret A., Eulitt, Patrick, Sarkar, Devanand, Dimitriev, Igor P., Chen, Ching-Shih, Grant, Steven, Curiel, David T., Fisher, Paul B., Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888700/
https://ncbi.nlm.nih.gov/pubmed/20107314
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