Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin-α Using Oriented Peptide Library Screening

Importin-α is the nuclear import receptor that recognizes the classic monopartite and bipartite nuclear localization sequences (cNLSs), which contain one or two clusters of basic amino acids, respectively. Different importin-α paralogs in a single organism are specific for distinct repertoires of ca...

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Detalhes bibliográficos
Main Authors: Yang, Sundy N. Y., Takeda, Agnes A. S., Fontes, Marcos R. M., Harris, Jonathan M., Jans, David A., Kobe, Boštjan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888405/
https://ncbi.nlm.nih.gov/pubmed/20406804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.079574
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