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State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation

The voltage-sensing domain of voltage-gated channels is comprised of four transmembrane helices (S1–S4), with conserved positively charged residues in S4 moving across the membrane in response to changes in transmembrane voltage. Although it has been shown that positive charges in S4 interact with n...

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Bibliographic Details
Main Authors: Wu, Dick, Delaloye, Kelli, Zaydman, Mark A., Nekouzadeh, Ali, Rudy, Yoram, Cui, Jianmin
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888051/
https://ncbi.nlm.nih.gov/pubmed/20479111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010408
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