The Emergence of Hematopoietic Stem Cells is Initiated in the Placental Vasculature in the Absence of Circulation

The mouse placenta was unveiled as an important reservoir for hematopoietic stem cells (HSCs), yet the origin of placental HSCs was unknown. By tracking developing HSCs by expression of Runx1-LacZ and CD41, we showed that HSCs emerge in large vessels in the placenta. Analysis of Ncx1(−/−) embryos, w...

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Главные авторы: Rhodes, Katrin E., Gekas, Christos, Wang, Yanling, Lux, Christopher T., Francis, Cameron S., Chan, David N., Conway, Simon, Orkin, Stuart H., Yoder, Mervin C., Mikkola, Hanna K.A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888040/
https://ncbi.nlm.nih.gov/pubmed/18371450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.01.001
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