Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling

The placenta is a hematopoietic organ that supports hematopoietic stem/progenitor cell (HSPC) generation and expansion without promoting differentiation. We identified PDGF-B signaling in trophoblasts as a key component of the unique placental hematopoietic microenvironment that protects HSPCs from...

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Autori principali: Chhabra, Akanksha, Lechner, Andrew J., Ueno, Masaya, Acharya, Asha, Van Handel, Ben, Wang, Yanling, Iruela-Arispe, M. Luisa, Tallquist, Michelle D., Mikkola, Hanna K.A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395466/
https://ncbi.nlm.nih.gov/pubmed/22387002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.12.022
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