Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics

Activation of ErbB receptors by epidermal growth factor (EGF) or heregulin (HRG) determines distinct cell fate decisions, although signals propagate through shared pathways. Using modeling and experiments, we unravel how EGF and HRG generate distinct, all-or-none responses of the phosphorylated tran...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nakakuki, Takashi, Birtwistle, Marc R., Saeki, Yuko, Yumoto, Noriko, Ide, Kaori, Nagashima, Takeshi, Brusch, Lutz, Ogunnaike, Babatunde A., Hatakeyama, Mariko, Kholodenko, Boris N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888034/
https://ncbi.nlm.nih.gov/pubmed/20493519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.03.054
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